Clinical Trials & Research

Mitochondria are compartments – so-called “organelles” — in our cells that provide the chemical energy supply we need to move, think, and live. Chloroplasts are organelles in plants and algae that capture sunlight and perform photosynthesis. At a first glance, they might look worlds apart. But an international team of researchers, led by the University

Blanchard CM, Chin MK, Gilhooly CH, Barger K, Matuszek G, Miki AJ, et al. Evaluation of PIQNIQ, a Novel Mobile Application for Capturing Dietary Intake. J Nutr. 2021;151:1347–56. Neuhouser ML, Tinker L, Shaw PA, Schoeller D, Bingham SA, Horn LV, et al. Use of recovery biomarkers to calibrate nutrient consumption self-reports in the Women’s Health

If a secretion in the lungs’ alveoli is not cleared regularly, breathing difficulties can develop. In a study published in Science Immunology, a team led by Alexander Mildner and Achim Leutz has now explained the pivotal role of the transcription factor C/EBPb in this process. The exchange of gases between the air we breathe and

Study design The CoLaus (Cohorte Lausannoise) study is a population-based prospective study assessing the clinical, biological, and genetic determinants of cardiovascular disease aged 35 to 75 years at baseline, living in the city of Lausanne, Switzerland)13. In each survey, participants answered questionnaires, underwent a clinical examination and blood samples were drawn for analyses13. Recruitment began in

A new publishing platform for open access biomedical research has launched. LSHTM Press will provide an open access platform to publish peer-reviewed research and high-quality educational resources, in accordance with the LSHTM mission to improve health and health equity in the UK and worldwide. The Press is a new initiative, developed in response to the

Target indicators The two target indicators of the proposed predictive models—the prevalence of people with insufficient food consumption and the prevalence of people using crisis or above-crisis food-based coping—are calculated on the basis of two household-level indicators: the FCS38 and the rCSI39, respectively. The FCS is calculated by asking each household how often, during the

The term ‘medical devices’ covers a wide range of products. These include surgical instruments and tools that are not left in the body or orthopedic and dental implants designed to remain inside the patient. There are highly restrictive parameters and controls surrounding the cleaning of these types of components, as expected, especially for surgical tools

An international research consortium led by UC San Francisco scientists has shown significant differences between the gut bacteria profiles of multiple sclerosis (MS) patients and healthy individuals, as well as between MS patients receiving different drug treatments. While some of these changes had been reported before, most are reported for the first time. The group

Application development The application took 6 months to build including creation of the databases, development of the design with a software engineer, and validation of the application. The development process involved professionals from the fields of nutrition and dietetics, and information technology. A total of 368 food items were included in the application as follows:

A team led by Van Andel Institute scientists has identified two distinct types of obesity with physiological and molecular differences that may have lifelong consequences for health, disease and response to medication. The findings, published today in the journal Nature Metabolism, offer a more nuanced understanding of obesity than current definitions and may one day

Small fish, such as mackerel, have a high nutritional value and a low carbon footprint.Credit: Getty Replacing meat with certain types of sustainably sourced seafood could help people to reduce their carbon footprints without compromising on nutrition, finds an analysis of dozens of marine species that are consumed worldwide. The study, published on 8 September

Frailty is defined as reduced physiological reserve and ability to cope with acute stresses. Up to half of adults over the age of 85 live with frailty and thus, preventative measures are greatly needed. Investigators at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, were interested in examining whether

Numerous cell and gene therapy solutions have exhibited promise as a source of potential treatment for an extensive range of chronic disorders. However, these innovative therapies typically introduce obstacles, such as necessitating ultra-low and cryogenic storage, which impact several steps of the life cycle of biomedical solutions, from their development to their administration. Image Credit: B Medical Systems

A new study published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) finds that there is a widening gap in diabetes-related mortality between urban and rural areas in the USA, and that reductions in mortality rates seen predominantly in urban areas have been mainly limited to female and older

Researchers at Queen’s University Belfast have developed a ground-breaking plastic film that can kill viruses that land on its surface with room light. The self-sterilizing film is the first of its kind – it is low cost to produce, can be readily scaled and could be used for disposable aprons, tablecloths, and curtains in hospitals.

Sponsored Content by GenScriptSep 8 2022Reviewed by Maria Osipova A novel immunotherapy tool has emerged in the last ten years. T cells engineered to express chimeric antigen receptors, commonly known as CAR T cells, have demonstrated the ability to help patients suffering from blood cancer. T cells engineered to express chimeric antigen receptors (CAR-T cells;

A team of researchers from the IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) has designed in silico “molecular probes” able to track the progress of a protein that misbehaves in different neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS) and Fronto-Temporal Dementia (FTD). The probes can be used to study the behavior of the

Sponsored Content by GenScriptSep 8 2022Reviewed by Maria Osipova Recently, GenScript made an announcement that demonstrated its commitment to supporting full non-viral cell therapy development into IND-enabling and clinical stages GenScript USA Inc., one of the global leaders as a services provider for the production of leading life-science research tools, announced the availability of new GMP-grade GenExact™ single-stranded

Chlamydia, the leading cause of sexually transmitted bacterial infections, evades detection and elimination inside human cells by use of a cloaking device. But Duke University researchers have grasped the hem of that invisibility cloak and now hope they can pull it apart. To enter the cell and peacefully reproduce, many pathogenic bacteria, including Chlamydia, cloak

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49. https://doi.org/10.3322/caac.21660. Article  PubMed  Google Scholar  Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F. Gastric cancer. Lancet

Sponsored Content by GenScriptSep 8 2022Reviewed by Maria Osipova GenScript USA Inc., a global leader in life science research tools and services, recently announced the launch of the GenWand™ Double-Stranded DNA (dsDNA) service for the production of CRISPR knock-in homology-directed repair (HDR) templates in T cell engineering. Closed-end dsDNA allows researchers to conduct gene knock-in with greater efficiency and lower

Today in Nature, University of Pittsburgh researchers describe for the first time a pathway by which cells repair damaged lysosomes, structures that contribute to longevity by recycling cellular trash. The findings are an important step towards understanding and treating age-related diseases driven by leaky lysosomes. Lysosome damage is a hallmark of aging and many diseases,