The novel Coronavirus infection often does not end with the acute phase of the disease but leaves medium and long-term effects. The most reported symptom in these cases is persistent fatigue. In foreground Dr. Elisa Brilli, Head of Research and Training Affairs PharmaNutra S.p.A. Image Credit: PharmaNutra S.p.A. A recent observational survey conducted in Italy
Clinical Trials & Research
PRINCETON, N.J., Sept. 7, 2021 – Those who are unvaccinated were nearly six times more likely to be hospitalized with severe COVID illness in August than those who have received the vaccine, according to a New Jersey Hospital Association analysis of COVID hospitalizations. Nearly three in every four patients hospitalized with COVID, or 73.3 percent,
Since its outbreak, the COVID-19 virus has infected more than 207.7 million people worldwide and has claimed more than 4.3 million lives, according to the World Health Organization coronavirus dashboard as of Aug. 17. However, many medical professionals attribute the consequential role of face masks in slowing the spread of the virus and protecting human
GAITHERSBURG, Md., Aug. 30, 2021. Novavax, Inc. , a biotechnology company developing next-generation vaccines for serious infectious diseases, today announced that the U.S. Centers for Disease Control and Prevention (CDC) has provided updated guidance for those who have been vaccinated as part of a clinical trial in the U.S. The CDC guidance states that participants
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, more than 220 million people have been infected, and approximately 4.56 million people have lost their lives worldwide. The causative agent of the pandemic is severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is a highly infectious RNA virus belonging to the family Coronaviridae. Study: Trajectory
MANHASSET, N.Y., Sept. 2, 2021. As part of a new National Institutes of Health (NIH) coronavirus disease 2019 (COVID-19) vaccine clinical trial, The Feinstein Institutes for Medical Research – the science arm of Northwell Health – delivered its first set of extra shots to eligible New York patients with an autoimmune disease. An estimated 8
A device that could make it possible for patients to draw their own blood at home was successfully used to collect blood samples for measuring antibodies against SARS-CoV-2, the virus that causes COVID-19, researchers at the University of Washington School of Medicine in Seattle report. The findings suggest the device could be used by patients
Wealthy Americans eat a better-balanced and more nutritious diet than do those in lower income groups, but their food habits are a bigger burden on the environment. Access options Access through your institution Change institution Buy or subscribe Subscribe to Journal Get full journal access for 1 year 199,00 € only 3,90 € per issue
Image Credit: Shutterstock.com/Indypendenz The answer to why some patients respond to therapy while others do not can be found in the concept of biomarkers: objective, measurable indicators of the severity or presence of disease. Used for decades to support medical diagnosis, today, researchers utilize biomarkers in all phases of drug discovery and development. There are
SAN FRANCISCO, Sept. 3, 2021. Quantum Leap Healthcare Collaborative, the sponsor of the I-SPY COVID Trial, today announced that the Famotidine Celecoxib arm has been dropped from the trial due to futility, based on the low likelihood of success. The Famotidine Celecoxib combination was chosen for testing because of their anti-histamine and anti-inflammatory mechanism of
The perseverance of scientists worldwide has led to the rapid development of many SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccines and provided preventative measures against the coronavirus 2019 (COVID-19) pandemic. However, there have been many cases of breakthrough infections, owing to the emergence of variants of concern (VoC), and scientists have noted some differences
1. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ. 2002;325:1202. PubMed PubMed Central Article Google Scholar 2. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002;288:2015–22. Article Google Scholar 3. De Ruijter W, Westendorp RG, Assendelft WJ, den Elzen
There is a low probability of success for immuno-oncology (IO) research. There is a below average likelihood-of-approval rate for oncology, usually 5.3% vs. 7.9% for all indications. The clinical trial success rate for biopharma and pharma drug developers can improve biomarkers by enhancing safety and by serving as surrogate clinical endpoints to allow for the
SOUTH SAN FRANCISCO, Calif., Sept. 1, 2021. Rigel Pharmaceuticals, Inc. today announced the publication of results from a Phase 2 clinical trial evaluating the safety of fostamatinib for the treatment of hospitalized patients with COVID-19, in Clinical Infectious Diseases, an official publication of the Infectious Disease Society of America. The study was sponsored by the
An Australian study conducted at the University of Melbourne describes that the emergence of more deadly variants of concern (VOCs) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with an induction in episodic evolutionary rate. The study is currently available on the medRxiv* preprint server. Background Whole-genome sequencing analysis is particularly important for
1. Di Cesare M, Soric M, Bovet P, Miranda JJ, Bhutta Z, Stevens GA, et al. The epidemiological burden of obesity in childhood: a worldwide epidemic requiring urgent action. BMC Med. 2019;17:212. PubMed PubMed Central Article Google Scholar 2. Kelly AS, Barlow SE, Rao G, Inge TH, Hayman LL, Steinberger J, et al. Severe obesity
Conducting a two-country clinical trial involving two assays and a nasopharyngeal swab may seem straightforward. However, amid Brexit and a global pandemic, this study was far from simple. Cerba Research was able to keep sample processing for a novel COVID-19 treatment on track in the middle of extraordinary upheaval through a combination of strong customer
MADRID, Aug. 31, 2021. Results from a new human clinical study demonstrate a significant capacity for Pharmactive’s potent all-natural affron standardized saffron extract to promote restorative sleep. The ingredient showed its effect in a single, low dose taken just one hour before bedtime, making affron a natural ingredient that is very easy to consume. Moreover,
Vaccines have high protective efficacy against infection or reinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic. A new review available on the medRxiv* preprint server showed that the protective effect of prior SARS-CoV-2 infection is at least equivalent to that of vaccination. Study:
To the best of our knowledge, this is the first prospective study demonstrated that two separate predictive equations is not necessary for acute (≤5 days) and late (≥6 days) phases of critical illness. Hence, we have developed and internally validated a single PE and demonstrated that it is useful for estimating the REE of both
PLYMOUTH MEETING, Pa., Aug. 26, 2021. INOVIO, a biotechnology company focused on bringing to market precisely designed DNA medicines to treat and protect people from infectious diseases, cancer, and HPV-associated diseases, today announced that it has received regulatory authorization from Brazil’s ANVISA (Agência Nacional de Vigilância Sanitária), the national health regulatory agency of Brazil, to
Several SARS-CoV-2 variants of concern have emerged since the start of the COVID-19 pandemic. Each bear mutations that may enhance transmissibility, allow SARS-CoV-2 to escape established immunity or otherwise alter the virus sufficiently to generate novel characteristics. The SARS-CoV-2 delta variant bears the D164G mutation, which is known to enhance viral fitness. However, a number
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