Allergies & Asthma

ZED1227, a potential therapeutic transglutaminase 2 inhibitor, reduced mucosal damage from gluten in celiac disease patients, a randomized proof-of-concept trial found. At week 6, the difference in villus height-to-crypt depth average ratio, a measurement of intestinal injury, was significant at three different dosages of ZED1227 (10 mg, 50 mg, and 100 mg) compared to placebo,
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Note that some links may require registration or subscription. COVID deaths in Brazil surpassed 500,000, and protesters in more than 20 cities are blaming President Jair Bolsonaro for downplaying the pandemic. (NPR) The more contagious and possibly more deadly Delta variant will “probably” become the dominant strain in the U.S. in the next couple of
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Among children with uncontrolled, moderate-to-severe asthma, treatment with the biologic dupilumab (Dupixent) was associated with a reduction in exacerbation and improvements in lung function in phase III findings from the international VOYAGE trial. Evidence of lung function improvement occurred within 2 weeks of treatment initiation, and was sustained during the 52-week randomized, placebo-controlled trial. Compared
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A first-in-class drug under development for severe asthma passed what its developers hope is the final test: achieving its primary endpoint in a phase III registration trial dubbed NAVIGATOR and now reported in a major journal. Tezepelumab, a monoclonal antibody targeting thymic stromal lymphopoietin (TSLP), cut the annualized rate of asthma exacerbations by more than
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A novel gene therapy for severe combined immunodeficiency from adenosine deaminase deficiency (ADA-SCID) restored immune cell counts without death or need for enzyme replacement therapy, researchers reported. Survival without needing to re-initiate pegylated ADA enzyme replacement therapy, or have a rescue allogeneic hematopoietic stem cell transplantation (AHCT), was 95% to 97% at last follow-up at
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You might think that when asthma patients were switched involuntarily from regular insurance to high-deductible health plans (HDHPs), a substantial number would cut corners on their daily controller medications — but you would mostly be wrong, researchers said. In fact, in a study of some 185,000 pediatric and adult patients with asthma spanning 2002 to
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Rather than site-wide food bans or allergen-restricted zones, allergy training, action plans, and available epinephrine to treat suspected anaphylaxis are recommended to address allergic reactions to food at child care centers and schools, according to new practice guidelines. Not only has research found little evidence that food bans work, such restrictions can pose monitoring and
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One of the most talked about food allergies is peanut. Though not the most common food allergy, it’s the most common food associated with severe allergic reactions – so it’s an important one to be educated on. Consider this overview on peanut allergy: from symptoms, diagnosis, and avoiding peanuts, to options for treating the cause.
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As the world starts to emerge from the COVID-19 crisis, another global — and even more devastating — existential threat persists: climate change. Worldwide, climate-driven disasters including storms, droughts, fires, and floods displaced more than 10 million people since last September. Here in the western U.S., we face increasingly catastrophic wildfire seasons with powerful effects
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Note that some links may require registration or subscription. A new coronavirus variant, BV-1, has been discovered in Texas. (Fox News) The European Medicines Agency said it found a “possible link” between the Johnson & Johnson COVID-19 vaccine and blood clots and recommended that a warning be added to the vaccine’s label, but they also
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