Clinical Trials & Research

Jun 14 2021 The British Liver Trust is calling for greater awareness of a silent yet serious form of fatty liver disease, non-alcohol related steatohepatitis (NASH), as one million adults were reported to have been admitted to hospital with obesity-related conditions in 2020.   Image Credit: British Liver Trust This call for action coincides with
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THOUSAND OAKS, Calif., June 4, 2021 /PRNewswire/ – Amgen (NASDAQ:AMGN) today announced updated results for investigational bemarituzumab in combination with chemotherapy from the Phase 2 FIGHT trial. The trial evaluated bemarituzumab plus chemotherapy (mFOLFOX6) versus chemotherapy alone in patients with FGFR2b-positive, HER2-negative frontline advanced gastric or gastroesophageal junction cancers (GEJ). New data includes median overall survival (OS), a secondary endpoint
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The term “doomscrolling” describes the act of endlessly scrolling through bad news on social media and reading every worrisome tidbit that pops up, a habit that unfortunately seems to have become common during the COVID-19 pandemic. The biology of our brains may play a role in that. Researchers at Washington University School of Medicine in
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Purpose With the introduction of pioneering technology for bacterial endotoxins testing (BET), it is critical to demonstrate equivalency across platforms. The Sievers Eclipse Ratio Verification Test was developed to confirm that the 1:1 ratio of sample to lysate typically used in a 96-well microplate is ever-present when utilizing the Eclipse BET microplate. Providing a 1:1 ratio
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TARRYTOWN, N.Y., June 4, 2021 /PRNewswire/ –  EUA supported by pivotal Phase 3 data showing 1,200 mg dose reduced risk of hospitalization or death by 70% Only antibody therapy currently available in all 50 states, including eight states with high rates of two variants of concern Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced the U.S. Food and
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A woman with pregnancy complications needed permission from her boss to visit a doctor. Community health volunteers were turned away from delivering food and covid information to worker housing. A farmworker had a serious allergic reaction but was afraid to seek treatment. To Nicole Civita, policy director with Colorado advocacy group Project Protect Food Systems
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1. Chan, J. C. et al. Diabetes in Asia: Epidemiology, risk factors, and pathophysiology. JAMA 301(20), 2129–2140 (2009). CAS  Article  Google Scholar  2. Nanditha, A. et al. Diabetes in Asia and the Pacific: Implications for the global epidemic. Diabetes Care 39(3), 472–485 (2016). CAS  Article  Google Scholar  3. International Diabetes Federation. IDF Diabetes Atlas, Ninth
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KENILWORTH, N.J.–(BUSINESS WIRE) June 9, 2021 — Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced it has entered into a procurement agreement with the United States government for molnupiravir (MK-4482). Molnupiravir is currently being evaluated in a Phase 3 clinical trial, the MOVe-OUT study, for the treatment of non-hospitalized
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A thorough overview of Bayesian networks, and probabilistic graphical models in general, can be found at the works of Pearl10, Koller and Friedman16, Bishop17, and Nagarajan and Scutari18. Overview of classical univariate and multivariate mixed-effects models can be found e.g. in Mehtätalo and Lappi13. Blei19 describes an iterative procedure of graphical model development and criticism
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Researchers in the United States and the UK have conducted a study showing how the B.1.1.7 (Alpha) lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adapted to suppress host innate immune responses in lung epithelial cells. The SARS-CoV-2 virus is the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic that continues to threaten
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1. Solon-Biet, S. M. et al. The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metab. 19, 418–430 (2014). CAS  PubMed  PubMed Central  Google Scholar  2. Lee, K. P. et al. Lifespan and reproduction in Drosophila: new insights from nutritional geometry. Proc. Natl Acad. Sci. USA
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TORONTO, May 25, 2021 — PharmaTher Holdings Ltd. (the “Company” or “PharmaTher”) (OTCQB: PHRRF) (CSE: PHRM), a clinical-stage psychedelics biotech company, is pleased to announce that it has filed an application with the U.S. Food and Drug Administration (“FDA”) to receive Orphan Drug Designation (“ODD”) for ketamine to treat amyotrophic lateral sclerosis (“ALS”), also known
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The rate of Kawasaki disease in South Korea has substantially decreased during the COVID-19 pandemic, possibly due to pandemic prevention efforts, such as mask-wearing, hand-washing and physical distancing, according to new research published today in the American Heart Association’s flagship journal Circulation. Kawasaki disease is the most common cause of heart disease that develops after
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1. Evelyn, J. The diary of John Evelyn 1st edn. (Nabu Press, Charleston, 1994). Google Scholar  2. Lau, B. F. et al. The potential of mycelium and culture broth of Lignosus rhinocerotis as substitutes for the naturally occurring sclerotium with regard to antioxidant capacity, cytotoxic effect, and low-molecular-weight chemical constituents. PLoS ONE 9(7), e102509-e (2014).
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Two-stage design will evaluate vaccine formulations targeting original D.614 virus as well as B.1.351 variant, in diverse geographies with multiple circulating variants A booster study programme will begin in the coming weeks to complement the Phase 3 trial Pending positive Phase 3 outcomes and regulatory reviews, the vaccine could be approved in Q4 2021 London
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1. Flint, H. J., Duncan, S. H., Scott, K. P. & Louis, P. Links between diet, gut microbiota composition and gut metabolism. Proc. Nutr. Soc. 74, 13–22 (2015). CAS  PubMed  Article  PubMed Central  Google Scholar  2. Salazar, N. et al. Exopolysaccharides produced by Bifidobacterium longum IPLA E44 and Bifidobacterium animalis subsp. lactis IPLA R1 modify
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June 1, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation (BTD) for teclistamab in the treatment of relapsed or refractory multiple myeloma. This distinction for teclistamab, an off-the-shelf, T-cell redirecting, bispecific antibody targeting both B-cell maturation antigen
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Once a virus infects a cell, neighboring cells are likely to become infected by interactions that are dependent on the cell and the virus in question. For example, cell-to-cell spread is facilitated in HIV by viral synapses, which also allow for escape from neutralizing antibodies. Low-level drug inhibitors are able to suppress infection if applied
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1. Rock, C. L. et al. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J. Clin. 62, 242–274 (2012). Article  Google Scholar  2. Lupton, J. R. et al. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids Vol. 5, 589–768 (National Academy Press, 2002). Google Scholar  3.
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