Children

Over a decade ago, UCLA physician-scientists began using a pioneering gene therapy they developed to treat children born with a rare and deadly immune system disorder. They now report that the effects of the therapy appear to be long-lasting, with 90% of patients who received the treatment eight to 11 years ago still disease-free. ADA-SCID,

An artificial intelligence (AI)-based technology rapidly diagnoses rare disorders in critically ill children with high accuracy, according to a report by scientists from University of Utah Health and Fabric Genomics, collaborators on a study led by Rady Children’s Hospital in San Diego. The benchmark finding, published in Genomic Medicine, foreshadows the next phase of medicine,

The emotional connection between a mother and her newborn baby can lay the foundation for the child’s development and the family’s outcomes. But poor mental health after giving birth can make it difficult for a mother to form this connection, known as mother-infant bonding. Given the rise of depression and anxiety symptoms due to the

Children with cerebral palsy can gain greater use of an impaired arm and hand with larger doses of Constraint-Induced Movement Therapy (CIMT) – without increasing stress for parents, according to a new study by researchers at Virginia Tech’s Fralin Biomedical Research Institute at VTC, UVA Children’s, The Ohio State University, and Nationwide Children’s Hospital. The

Intravenous immune globulin (IVIG) — a common treatment for multisystem inflammatory syndrome in children (MIS-C) — likely works by depleting immune cells called neutrophils, according to a recent study funded by the National Institutes of Health (NIH). MIS-C is a rare condition that usually affects school-age children who initially had only mild COVID-19 symptoms or

Young adults who experience a traumatic injury are now more likely to have insurance coverage and access to rehabilitation if they live in a state that expanded Medicaid under the Affordable Care Act (ACA), new study findings show. Further, states that expanded Medicaid also saw greater reductions in socioeconomic and racial disparities in certain areas,

Children from less affluent backgrounds are likely to have found COVID-19 lockdowns more challenging to their mental health because they experienced a lower connection with nature than their wealthier peers, a new study suggests. A study has found that children who increased their connection to nature during the first COVID-19 lockdown were likely to have

Children with hemiparetic cerebral palsy, a movement disorder that affects use of one side of the body, showed improved use of the arm and hand after receiving a high dose of Constraint-Induced Movement Therapy (CIMT) in a clinical trial funded by the National Institutes of Health. The study, published in Pediatrics, suggests that the more

There has been a considerable amount of controversy surrounding whether pregnant women with the coronavirus disease 2019 (COVID-19) are at a higher risk for poor outcomes for themselves and their babies. A recent study suggests the answer depends on the presence of symptoms at near term. “Most pregnancy and delivery outcomes were similar between COVID-19-positive

In an unprecedented effort to address the harmful effects of structural racism on health, 60 predominantly Black neighborhoods in Philadelphia will be part of an ambitious study to assess the impact of a multi-component intervention addressing both environmental and economic injustice on health and well-being, led by Penn Medicine researchers Eugenia C. South, MD, MHSP,

The findings of a new study suggest that childhood adversity is a major contributor to early and preventable causes of mortality and a powerful determinant of long term physical and mental health. Researchers at Columbia University Mailman School of Public Health and Harvard University found that childhood adversity is associated with elevated risk for chronic

One way to make health care more personalized is to use a person’s DNA sequence — or genome — to predict their risk of disease. But as the field of precision medicine grows, so have concerns that we may be leaving a large fraction of Americans out. Disease prevalence and severity can vary considerably across

A vaccine has proved safe and effective in protecting children against typhoid, raising hopes of fighting the disease in Sub-Saharan Africa, a study says. More than 1.2 million cases of typhoid and 18,703 deaths from typhoid occur every year in the region, according to the researchers. The World Health Organization (WHO) recommended the typhoid conjugate

The phone rang into the pediatric unit that Louise Markert, M.D., Ph.D., was staffing as a junior faculty member in 1991. Had she not answered, there would have been little hope for the more than one hundred patients who were subsequently treated. The call was from a doctor in Tennessee, seeking insights from Duke’s renown

The COVID-19 pandemic forced the hand of many. Schools, universities, businesses – nearly every organization that provides any form of in-person education either began offering or enhanced their online programming. But even years before the pandemic, online learning was growing in popularity. In 2018, more than 100 million learners enrolled in massive open online courses

Researchers with Johns Hopkins Children’s Center found that more than half of all violence-related injuries in youth treated in the emergency department (ED) were due to family violence, including child maltreatment and physical fighting. Most events involved parents or guardians. The researchers also found the majority of family violence-related injury happened at home, and the

The World Health Organization (WHO) is recommending widespread use of the RTS,S/AS01 (RTS,S) malaria vaccine among children in sub-Saharan Africa and in other regions with moderate to high P. falciparum malaria transmission. The recommendation is based on results from an ongoing pilot programme in Ghana, Kenya and Malawi that has reached more than 800 000

Researchers at the Icahn School of Medicine at Mount Sinai have developed a novel machine learning algorithm and used it to identify previously unknown mixtures of toxic air pollutants that appear to be linked to poor asthma outcomes later in a child’s life. The study examined early exposure to dozens of pollutants potentially experienced by

Stringent lockdown measures imposed in the spring of 2020 led to a dramatic drop in vaccinations among both children and adults, according to a new study led by Children’s Hospital of Philadelphia (CHOP). The study, which focused on data from Michigan, also found a decrease in sites providing pediatric vaccinations, particularly those dedicated to caring

Parent Project Muscular Dystrophy (PPMD), a nonprofit organization leading the fight to end Duchenne muscular dystrophy (Duchenne), announced that the organization’s Newborn Screening Pilot has successfully reached its completion, screening more than 36,000 babies born in New York State over the last two years. Data were presented today at the Association of Public Health Laboratories

Antibiotics alone likely cannot overcome the complex factors that cause stunted growth and perpetuate the cycle of poverty in the developing world, new research suggests. To prevent stunted growth in the developing world, a “much more comprehensive approach” is needed than antibiotics alone, said Mark DeBoer, MD, of UVA Children’s. Image Credit: UVA Health An

Thirteen-year-old Gregory Rhoden’s condition has been a mystery his entire life. He was born prematurely and his lungs seemed underdeveloped. While he had some respiratory issues growing up, it wasn’t until a running event in kindergarten that he began complaining of chest pain and shortness of breath. A doctor labeled Gregory’s symptoms as asthma and