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After looking closely at the drug-drug interactions listed for Pfizer’s new oral COVID-19 drug ritonavir-nirmatrelvir (Paxlovid), I realized that a large percentage of my patients are taking medications on the list. The antiviral was granted FDA emergency use authorization in late December for the treatment of mild-to-moderate COVID-19 in patients at high risk of severe
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More data support the concept of stroke-related restless legs syndrome as an “emerging entity,” investigators report in a new study. New research has identified the lenticulostriate and ventral brainstem as the main regions implicated in stroke-related restless leg syndrome (s-RLS). Researchers also observed dopaminergic dysfunction in patients with sRLS. “Clinicians should be aware of sRLS
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When it comes to antidepressant prescribing, less may be more, new research suggests. A new review suggests antidepressants are overprescribed and that the efficacy of these agents is questionable, leading researchers to recommend that when physicians prescribe these medications, it should be for shorter periods. “Antidepressants have never been shown to have a clinically significant
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Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Commercial and Medicare Advantage insurers are spending an estimated $129.7 million annually on ivermectin prescriptions for COVID-19, even though the antiparasitic drug has not been shown to be effective against the virus, according to a new JAMA study. The researchers analyzed
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The Isotretinoin Products Manufacturers Group (IPMG) reports that most users of the iPLEDGE Risk Evaluation and Mitigation Strategy (REMS) should now have access to their accounts, one month after a modified program was launched, the Food and Drug Administration announced on Jan. 14. The IPMG has “created a new tool within the system to help resolve account access
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Subscribe to Second Opinion for a weekly roundup of health and medical science news. A Canadian study that vastly underestimated the protection COVID-19 vaccines provide against the Omicron variant is being revised — but not before it spread widely on social media by anti-vaxxers, academics and even the creators of the Russian Sputnik V vaccine. The Ontario
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The Food and Drug Administration on Jan. 14 approved two oral JAK-1 inhibitors for patients with moderate-to-severe atopic dermatitis (AD) — upadacitinib and abrocitinib — making them the first oral JAK inhibitors available for this indication in the United States. “It’s big news because a few years ago we didn’t have any systemic treatments that are safer
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The Medicare Payment Advisory Commission (MedPAC) voted unanimously to support a recommendation of no change to the physician fee schedule for fiscal year 2023 on Thursday, provoking immediate backlash from the American Medical Association (AMA) and other medical groups. A combination of inflation plus lost revenue during the COVID-19 pandemic sparked concern. Under current law,
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Flu vaccines prevented the majority of critical and life-threatening influenza cases among children during the 2019-2020 season, a case-control study found. Vaccine effectiveness was 63% (95% CI 38-78%) against “critical influenza” and 75% (95% CI 49-88%) against “life-threatening influenza,” reported Manish Patel, MD, of the CDC, and colleagues in Clinical Infectious Diseases. CDC Director Rochelle
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