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Field cancerization and subsequent second cancer in squamous cell carcinoma (SCC) patients was significantly associated with cigarette and alcohol use, based on data from more than 300 individuals. Cigarette and alcohol use are established risk factors for SCCs of the esophagus, head, and neck, Manabu Moto, MD, of Kyoto University, and colleagues wrote. “In addition,
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Researchers have identified a potential cause of molar hypomineralization (MH), or “chalky teeth,” an underrecognized condition affecting 1 in 5 children worldwide. The discovery could lead to preventive medical therapies to reduce dental caries and extractions, they said. According to a team led by biochemist Michael J. Hubbard, BDS, PhD, a professor in the Faculty
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Patients with severe generalized pustular psoriasis (GPP) had rapid clearance of skin lesions when treated with an investigational interleukin (IL)-36 inhibitor, a small randomized trial showed. One week after treatment with intravenous spesolimab, more than half of patients with GPP had complete clearance of skin pustules. In contrast, only 6% of placebo-treated patients met clinical
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At Kristen’s Pharmacy in Southampton, Ont., the day begins with staff shuffling in for their COVID-19 symptom screenings, temperature checks and daily rapid tests. Doors and phone lines open at 9 a.m., and from then until roughly noon, it’s “utter pandemonium,” according to owner and pharmacist Kristen Watt. Eight phones ring off the hook; the
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Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. The US Food and Drug Administration (FDA) granted emergency use authorization to Merck’s antiviral drug to treat adults with mild to moderate COVID-19 who are at risk for severe disease. Similar to FDA authorization of another antiviral pill regimen ― ritonavir
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The US Food and Drug Administration (FDA) has approved inclisiran (Leqvio) as an adjunct to statins for further reduction of LDL cholesterol levels, the drug’s developer, Novartis, announced today. The first-in-class small interfering RNA (siRNA) agent is also novel among peer drug therapies for its administration by injection initially, at three months, and thereafter twice
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FDA finally approved inclisiran (Leqvio), making it the first small interfering RNA (siRNA) therapy to hit the market for reducing LDL cholesterol, Novartis announced on Wednesday. The PCSK9 inhibitor was handed an indication as an adjunct to diet and maximally-tolerated statin therapy for the treatment of adults with clinical atherosclerotic cardiovascular disease or heterozygous familial
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Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. The impact of respiratory syncytial virus (RSV)will likely be greater in 2021 and 2022 in the United States than in previous years as a result of the ongoing COVID-19 pandemic, based on data from a simulation-modeling study involving approximately 19 million
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