Being a scientist

Clinical Trials & Research
  • 1.

    Keys A, Brozek J, Henschel A, Mickelsen O, Taylor HL. The biology of human starvation. Minneapolis (MN): The University of Minnesota Press; 1950.

  • 2.

    Krebs HA, Veech RL. Equilibrium relations between pyridine nucleotides and adenine nucleotides and their roles in the regulation of metabolic processes. Adv Enzym Regul. 1969;7:397–413.

    CAS 

    Google Scholar
     

  • 3.

    Cahill GF Jr. Starvation in man. N Engl J Med. 1970;282:668–75.

    CAS 
    PubMed 

    Google Scholar
     

  • 4.

    Felig P, Wahren J, Hendler R. Influence of oral glucose ingestion on splanchnic glucose and gluconeogenic substrate metabolism in man. Diabetes. 1975;24:468–75.

    CAS 
    PubMed 

    Google Scholar
     

  • 5.

    Seitz HJ, Müller MJ, Krone W, Tarnowski W. Coordinate control of intermediary metabolism in rat liverby the insulin/glucagon ratio during starvation and after glucose refeeding. Arch Biochem Biophys. 1977;183:647–63.

    CAS 
    PubMed 

    Google Scholar
     

  • 6.

    Seitz HJ, Kaiser M, Krone W, Tarnowski W. Physiologic significance of glucocorticoids and insulin in the regulation of hepatic gluconeogenesis during starvation in rats. Metabolism. 1976;25:1545–55.

    CAS 
    PubMed 

    Google Scholar
     

  • 7.

    Müller MJ, Paschen U, Seitz HJ. Glucose production measured by tracer and balance data in conscious miniature pig. Am J Physiol. 1983;244:E236–244.

    PubMed 

    Google Scholar
     

  • 8.

    Müller MJ, Paschen U, Seitz HJ. Effect of ketone bodies on glucose production and utilization in the miniature pig. J Clin Investig. 1984;74:249–61.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • 9.

    Müller MJ, Köster H, Seitz HJ. Effect of thyroid state on ketogenic capacity of the isolated perfused liver of starved rats. Biochem Biophys Acta. 1981;666:475–81.

    PubMed 

    Google Scholar
     

  • 10.

    Müller MJ, Seitz HJ. Pleiotypic action of thyroid hormones at the target cell level. Biochem Pharmacol. 1984;33:1579–84.

    PubMed 

    Google Scholar
     

  • 11.

    Müller MJ, Acheson KJ, Jequier E, Burger AG. Effect of thyroid hormones on oxidative and non-oxidative glucose metabolism in humans. Am J Physiol. 1988;255:E146–E152.

    PubMed 

    Google Scholar
     

  • 12.

    Müller MJ, von Schütz B, Huhnt HJ, Zick R, Mitzkat HJ, von zur Mühlen A. Glucoregulatory function of thyroid hormones: interaction with insulin depends on the prevailing glucose concentration. J Clin Endocrinol Metab. 1986;63:62–71.

    PubMed 

    Google Scholar
     

  • 13.

    Selberg O, Burchert W, vd Hoff J, Meyer GJ, Hundeshagen H, Radoch E, et al. Insulin resistance in liver cirrhosis. Positron-emission tomography scan analysis of skeletal muscle glucose metabolism. J Clin Investig. 1993;91:1897–902.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • 14.

    Müller MJ, von zur Mühlen A, Lautz HU, Schmidt FW, Daiber M, Hürter P. Energy expenditure in children with type I diabetes: evidence for increased thermogenesis. BMJ. 1989;299:487–91.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • 15.

    Müller MJ, Burger AG, Ferraninni E, Jequier E, Acheson K. Glucoregulatory function of thyroid hormones: Role of pancreatic hormones. Am J Physiol. 1989;256:E101–E110.

    PubMed 

    Google Scholar
     

  • 16.

    Müller MJ, Seitz HJ. Interrelation between thyroid state and the effect of glucagon on gluconeogenesis in perfused rat livers. Biochem Pharmacol. 1987;36:1623–7.

    PubMed 

    Google Scholar
     

  • 17.

    Müller MJ, Willmann O, Fenk A, Rieger A, Selberg O, Canzler H, et al. Resting energy expenditure and the thermic effect of adrenaline in patients with liver cirrhosis. Clin Sci. 1992;83:191–8.


    Google Scholar
     

  • 18.

    Müller MJ, Acheson KJ, Piolino V, Jeanpretre N, Burger AG, Jequier E. Thermic effect of epinephrine: a role for endogenous insulin. Metabolism. 1992;41:582–7.

    PubMed 

    Google Scholar
     

  • 19.

    Müller MJ, Lautz HU, Plogmann B, Bürger M, Körber J, Schmidt FW. Energy expenditure and substrate oxidation in patients with cirrhosis: The impact of cause, clinical staging and nutritional state. Hepatology. 1992;15:782–94.

    PubMed 

    Google Scholar
     

  • 20.

    Müller MJ, Böttcher J, Selberg O, Weselmann S, Böker KHW, Schwarze M, et al. Hypermetabolism in clinically stable patients with liver cirrhosis. Am J Clin Nutr. 1999;69:1194–201.

    PubMed 

    Google Scholar
     

  • 21.

    Müller MJ, Loyal S, Schwarze M, Lobers J, Selberg O, Ringe B, et al. Resting energy expenditure and nutritional state in patients with liver cirrhosis before and after liver transplantation. Clin Nutr. 1994;13:145–52.

    PubMed 

    Google Scholar
     

  • 22.

    Müller MJ. Hepatic fuel selection. Proc Nutr Soc. 1995;54:139–50.

    PubMed 

    Google Scholar
     

  • 23.

    Müller MJ. Hepatic energy and substrate metabolism: a possible metabolic basis for early nutritional support in cirrhotic patients. Nutrition. 1998;14:30–38.

    PubMed 

    Google Scholar
     

  • 24.

    Müller MJ, Bosy-Westphal A, Klaus S, Kreymann G, Lührmann P, Neuhäuser-Berthold M, et al. World Health Organization equations have shortcomings for predicting resting energy expenditure in persons from modern affluent populations: generation of a new reference standard from a retrospective analysis of a German database of resting energy expenditure. Am J Clin Nutr. 2004;80:1379–90.

    PubMed 

    Google Scholar
     

  • 25.

    Müller MJ, Geisler C, Hübers M, Pourhassan M, Braun W, Bosy-Westphal A. Normalizing resting energy expenditure across the life course in humans: challenges and hopes. Eur J Clin Nutr. 2018;72:628–37.

    PubMed 

    Google Scholar
     

  • 26.

    Müller MJ, Lagerpusch M, Enderle J, Schautz B, Heller M, Bosy-Westphal A. Beyond the body mass index: tracking body composition in the pathogenesis of obesity and the metabolic syndrome. Obes Rev. 2012;13 Suppl. 2:6–13.

    PubMed 

    Google Scholar
     

  • 27.

    Müller MJ, Braun W, Enderle J, Bosy-Westphal A. Beyond BMI: conceptual issues related to overweight and obese patients. Obes Facts. 2016;9:193–205.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • 28.

    Müller MJ, Bosy-Westphal A, Later W, Haas V, Heller M. Functional body composition: insights into the regulation of energy metabolism and some clinical applications. Eur J Clin Nutr. 2009;63:1045–56.

    PubMed 

    Google Scholar
     

  • 29.

    Müller MJ, Braun W, Pourhassan M, Geisler C, Bosy-Westphal A. Application of standards and models in body composition analysis. Proc Nutr Soc. 2016;75:181–7.

    PubMed 

    Google Scholar
     

  • 30.

    Müller MJ, Geisler C, Hübers M, Pourhassan M, Bosy-Westphal A. Body composition-related functions: a problem-orientated approach to phenotyping. Eur J Clin Nutr. 2019;73:179–86.

    PubMed 

    Google Scholar
     

  • 31.

    Heymsfield SB, Thomas D, Nguyen AM, Peng JZ, Shen W, Strauss B, et al. Voluntary weight loss: systematic review of early phase body composition changes. Obes Rev. 2011;12:e348–e361.

    CAS 
    PubMed 

    Google Scholar
     

  • 32.

    Heymsfield SB, Smith B, Dahle J, Kennedy S, Fearnbach N, Thomas D, et al. Resting energy expenditure: From cellular to whole-body level, a mechanistic historical perspective. Obesity. 2021;29:500–11.

    PubMed 

    Google Scholar
     

  • 33.

    Müller MJ, Enderle J, Pourhassan M, Braun W, Eggeling B, Lagerpusch M, et al. Metabolic adaptation to caloric restriction and subsequent refeeding: the Minnesota Starvation Experiment revisited. Am J Clin Nutr. 2015;102:807–19.

    PubMed 

    Google Scholar
     

  • 34.

    Müller MJ, Enderle J, Bosy-Westphal A. Changes in energy expenditure with weight gain and weight loss in humans. Curr Obes Rep. 2016;5:413–23.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • 35.

    Müller MJ, Heymsfield SB, Bosy-Westphal A. Are metabolic adaptations to weight changes an artefact? Am J Clin Nutr. 2021;114:1386–95.

    PubMed 

    Google Scholar
     

  • 36.

    Hägele FA, Büsing F, Nas A, Hasler M, Müller MJ, Blundell J, et al. Appetite control is improved by acute increases in energy turnover at different levels of energy balance. J Clin Endocr Metab. 2019;104:4481–91.

    PubMed 

    Google Scholar
     

  • 37.

    Bosy-Westphal A, Hägele FA, Müller MJ. Impact of energy turnover on the regulation of energy and macronutrient balance. Obesity. 2021;29:1114–9.

    CAS 
    PubMed 

    Google Scholar
     

  • 38.

    Bosy-Westphal A, Hägele FA, Müller MJ. What is the impact of energy expenditure on energy intake? Nutrients. 2021;13:3508.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • 39.

    Danielzik S, Czerwinski-Mast M, Langnäse K, Dilba B, Müller MJ. Parental overweight, socioeconomic status and high birth weight are the major determinants of overweight and obesity in 5-7-y-old children: baseline data of the Kiel Obesity Prevention Study. Int J Obes. 2004;28:1494–502.

    CAS 

    Google Scholar
     

  • 40.

    Plachta-Danielzik S, Pust S, Asbeck I, Czerwinski-Mast M, Langnäse K, Fischer C, et al. Four-year follow-up of school-based intervention on overweight children: the KOPS study. Obesity. 2007;15:3159–69.

    PubMed 

    Google Scholar
     

  • 41.

    Danielzik S, Kehden B, Landsberg B, Schaffrath-Rosario A, Kurth B-M, Arnold C, et al. Attributable risks for childhood overweight: evidence for limited effectiveness of prevention. Pediatrics. 2012;130:e865–e871.


    Google Scholar
     

  • 42.

    Müller MJ. How are we going to turn the obesity prevention experience? Obes Rev. 2009;11:101–4.

    PubMed 

    Google Scholar
     

  • 43.

    Swinburn B, Kraak VL, Allender S, Atkins VJ, Baker PI, Bogard JR, et al. The gobal syndemic of obesity, undernutrition and climate change: The Lancet Report. Lancet. 2019;393:791–846.

    PubMed 

    Google Scholar
     

  • 44.

    Müller MJ, Geisler C, Blundell J, Dulloo A, Schutz Y, Krawczak M, et al. The case of GWAS of obesity: does body weight control play by the rules? Int J Obes. 2018;42:1395–405.


    Google Scholar
     

  • 45.

    Müller MJ, Bosy-Westphal A. From a “Metabolomic Fashion” to a sound application of metabolomics in research on human nutrition. Eur J Clin Nutr. 2020;74:1619–29.

    PubMed 

    Google Scholar
     

  • 46.

    Amrheim V, Greenland S, McShane B. Retire statistical significance. Nature. 2019;567:305–7.


    Google Scholar
     

  • 47.

    Wasserman RL, Schirm AL, Lazar MA. Statistical inference in the 21st century: a world beyond P < 0.05. Am Statistician. 2019;73 Suppl 1:1–19.


    Google Scholar
     

  • 48.

    Müller MJ, Landsberg B, Ried J. Fraud in science: a plea for a new culture in research. Eur J Clin Nutr 2014;68:411–5.

    PubMed 

    Google Scholar
     

  • 49.

    Müller MJ, Landsberg B, Ried J. Fraud in science: a plea for a new culture in research. Int J Obes. 2014;38:572–76.


    Google Scholar
     

  • 50.

    Müller MJ, Soares M. The ethics of research publications. Eur J Clin Nutr. 2017;71:569.

    PubMed 

    Google Scholar
     

  • 51.

    Midgley M. Science as salvation. London, UK: Routledge Classic; 1992.

  • 52.

    Feyerabend P. The Tyranny of Science. Cambridge, UK: Polity Press; 2011.

  • 53.

    Hannah Arendt. The human condition. 1st ed., Chicago, IL, USA: University of Chicago Press; 1958.

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