The effects of chromium supplementation on blood pressure: a systematic review and meta-analysis of randomized clinical trials

Clinical Trials & Research
  • 1.

    Kumar J. Epidemiology of hypertension. Clin Queries: Nephrol. 2013;2:56–61.

    Article 

    Google Scholar
     

  • 2.

    Fuchs FD, Whelton PK. High blood pressure and cardiovascular disease. Hypertension. 2020;75:285–92.

    CAS 
    Article 

    Google Scholar
     

  • 3.

    Matsumoto K, Jin Z, Homma S, Elkind MS, Rundek T, Mannina C, et al. Association between central blood pressure and subclinical cerebrovascular disease in older adults. Hypertension. 2020;75:580–7.

    CAS 
    Article 

    Google Scholar
     

  • 4.

    Tozawa M, Iseki K, Iseki C, Kinjo K, Ikemiya Y, Takishita S. Blood pressure predicts risk of developing end-stage renal disease in men and women. Hypertension. 2003;41:1341–5.

    CAS 
    Article 

    Google Scholar
     

  • 5.

    Castro I, Waclawovsky G, Marcadenti A. Nutrition and physical activity on hypertension: implication of current evidence and guidelines. Curr Hypertens Rev. 2015;11:91–9.

    Article 

    Google Scholar
     

  • 6.

    Askarpour M, Ghaedi E, Roshanravan N, Hadi A, Mohammadi H, Symonds ME, et al. Policosanol supplementation significantly improves blood pressure among adults: a systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2019.

  • 7.

    Elmer PJ, Obarzanek E, Vollmer WM, Simons-Morton D, Stevens VJ, Young DR, et al. Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial. Ann Intern Med. 2006;144:485–95.

    Article 

    Google Scholar
     

  • 8.

    Xin X, He J, Frontini MG, Ogden LG, Motsamai OI, Whelton PK. Effects of alcohol reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2001;38:1112–7.

    CAS 
    Article 

    Google Scholar
     

  • 9.

    Avila-Palencia I, Laeremans M, Hoffmann B, Anaya-Boig E, Carrasco-Turigas G, Cole-Hunter T, et al. Effects of physical activity and air pollution on blood pressure. Environ Res. 2019;173:387–96.

    CAS 
    Article 

    Google Scholar
     

  • 10.

    Cooper JA, Anderson BF, Buckley PD, Blackwell LF. Structure and biological activity of nitrogen and oxygen coordinated nicotinic acid complexes of chromium. Inorg Chim Acta. 1984;91:1–9.

    CAS 
    Article 

    Google Scholar
     

  • 11.

    Preuss H, Grojec P, Lieberman S, Anderson R. Effects of different chromium compounds on blood pressure and lipid peroxidation in spontaneously hypertensive rats. Clin Nephrol. 1997;47:325–30.

    CAS 
    PubMed 

    Google Scholar
     

  • 12.

    EFSA Panel on Dietetic Products N, Allergies. Scientific opinion on dietary reference values for chromium. EFSA J 2014;12:3845.

    Article 

    Google Scholar
     

  • 13.

    Tao Y, editor. Progress in chromium research and related diseases. AIP Conference Proceedings; 2019. AIP Publishing LLC.

  • 14.

    Preuss HG, Echard B, Perricone NV, Bagchi D, Yasmin T, Stohs SJ. Comparing metabolic effects of six different commercial trivalent chromium compounds. J Inorg Biochem. 2008;102:1986–90.

    CAS 
    Article 

    Google Scholar
     

  • 15.

    Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal V. Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes. J Trace Elem Med Biol. 2011;25:149–53.

    CAS 
    Article 

    Google Scholar
     

  • 16.

    Vrtovec M, Vrtovec B, Briski A, Kocijancic A, Anderson RA, Radovancevic B. Chromium supplementation shortens QTc interval duration in patients with type 2 diabetes mellitus. Am Heart J. 2005;149:632–6.

    CAS 
    Article 

    Google Scholar
     

  • 17.

    Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151:264–9. w64

    Article 

    Google Scholar
     

  • 18.

    Higgins J, Green S. Assessing risk of bias in included studies. Cochrane handbook for systematic reviews of interventions Version 5.1. 0; 2011. 2008.

  • 19.

    Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005;5:13.

    Article 

    Google Scholar
     

  • 20.

    Chen Y-L, Lin J-D, Hsia T-L, Mao FC, Hsu C-H, Pei D. The effect of chromium on inflammatory markers, 1st and 2nd phase insulin secretion in type 2 diabetes. Eur J Nutr. 2014;53:127–33.

    CAS 
    Article 

    Google Scholar
     

  • 21.

    Kleefstra N, Houweling ST, Bakker SJ, Verhoeven S, Gans RO, Meyboom-de JB. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care. 2007;30:1092–6.

    CAS 
    Article 

    Google Scholar
     

  • 22.

    Ali A, Ma Y, Reynolds J, Wise J Sr, Inzucchi S, Katz D. Chromium effects on glucose tolerance and insulin sensitivity in persons at risk for diabetes mellitus. Endocr Pract. 2011;17:16–25.

    Article 

    Google Scholar
     

  • 23.

    Farrokhian A, Mahmoodian M, Bahmani F, Amirani E, Shafabakhsh R, Asemi Z. The influences of chromium supplementation on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease. Biol Trace Elem Res. 2020;194:313–20.

    CAS 
    Article 

    Google Scholar
     

  • 24.

    Kleefstra N, Houweling ST, Jansman FG, Groenier KH, Gans RO, Meyboom-de Jong B, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care. 2006;29:521–5.

    CAS 
    Article 

    Google Scholar
     

  • 25.

    Nussbaumerova B, Rosolova H, Krizek M, Sefrna F, Racek J, Müller L, et al. Chromium supplementation reduces resting heart rate in patients with metabolic syndrome and impaired glucose tolerance. Biol Trace Elem Res. 2018;183:192–9.

    CAS 
    Article 

    Google Scholar
     

  • 26.

    Yazaki Y, Faridi Z, Ma Y, Ali A, Northrup V, Njike VY, et al. A pilot study of chromium picolinate for weight loss. J Alter Complement Med. 2010;16:291–9.

    Article 

    Google Scholar
     

  • 27.

    Imanparast F, Javaheri J, Kamankesh F, Rafiei F, Salehi A, Mollaaliakbari Z, et al. The effects of chromium and vitamin D3 co-supplementation on insulin resistance and tumor necrosis factor-alpha in type 2 diabetes: a randomized placebo-controlled trial. Appl Physiol Nutr Metab. 2020;45:471–7.

    CAS 
    Article 

    Google Scholar
     

  • 28.

    Cefalu WT, Hu FB. Role of chromium in human health and in diabetes. Diabetes Care. 2004;27:2741–51.

    CAS 
    Article 

    Google Scholar
     

  • 29.

    DesMarias TL, Costa M. Mechanisms of chromium-induced toxicity. Curr Opin Toxicol. 2019;14:1–7.

    Article 

    Google Scholar
     

  • 30.

    Asbaghi O, Fatemeh N, Mahnaz RK, Ehsan G, Elham E, Behzad N, et al. Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Pharmacol. Res. 2020:105098.

  • 31.

    Asbaghi O, Naeini F, Ashtary-Larky D, Moradi S, Zakeri N, Eslampour E, et al. Effects of chromium supplementation on lipid profile in patients with type 2 diabetes: a systematic review and dose-response meta-analysis of randomized controlled trials. J Trace Elem Med Biol. 2021:126741.

  • 32.

    Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuñiga FA. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol. 2018;17:1–14.

    Article 

    Google Scholar
     

  • 33.

    Choudhury KN, Mainuddin A, Wahiduzzaman M, Islam SMS. Serum lipid profile and its association with hypertension in Bangladesh. Vasc Health Risk Manag. 2014;10:327.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • 34.

    Ngala RA, Awe MA, Nsiah P. The effects of plasma chromium on lipid profile, glucose metabolism and cardiovascular risk in type 2 diabetes mellitus. A case-control study. PLoS ONE. 2018;13:e0197977.

    Article 

    Google Scholar
     

  • 35.

    Mozaffari MS, Baban B, Abdelsayed R, Liu JY, Wimborne H, Rodriguez N, et al. Renal and glycemic effects of high-dose chromium picolinate in db/db mice: assessment of DNA damage. J Nutr Biochem. 2012;23:977–85.

    CAS 
    Article 

    Google Scholar
     

  • 36.

    Anderson EA, Hoffman R, Balon T, Sinkey C, Mark A. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. Eur J Clin Investig. 1991;87:2246–52.

    CAS 
    Article 

    Google Scholar
     

  • 37.

    Perlstein TS, Gerhard-Herman M, Hollenberg NK, Williams GH, Thomas A. Insulin induces renal vasodilation, increases plasma renin activity, and sensitizes the renal vasculature to angiotensin receptor blockade in healthy subjects. J Am Soc Nephrol. 2007;18:944–51.

    CAS 
    Article 

    Google Scholar
     

  • 38.

    Suksomboon N, Poolsup N, Yuwanakorn A. Systematic review and meta‐analysis of the efficacy and safety of chromium supplementation in diabetes. J Clin Pharm Ther. 2014;39:292–306.

    CAS 
    Article 

    Google Scholar
     

  • 39.

    Vincent JB. The biochemistry of chromium. J Nutr. 2000;130:715–8.

    CAS 
    Article 

    Google Scholar
     

  • 40.

    Lewicki S, Zdanowski R, Krzyzowska M, Lewicka A, Debski B, Niemcewicz M, et al. The role of Chromium III in the organism and its possible use in diabetes and obesity treatment. Ann Agric Environ Med. 2014;21:331–5.

    CAS 
    Article 

    Google Scholar
     

  • 41.

    Offenbacher EG, Pi-Sunyer FX. Beneficial effect of chromium-rich yeast on glucose tolerance and blood lipids in elderly subjects. Diabetes 1980;29:919–25.

    CAS 
    Article 

    Google Scholar
     

  • 42.

    Sadeghi M, Najaf Panah MJ, Bakhtiarizadeh MR, Emami A. Transcription analysis of genes involved in lipid metabolism reveals the role of chromium in reducing body fat in animal models. J Trace Elem Med Biol. 2015;32:45–51.

    CAS 
    Article 

    Google Scholar
     

  • 43.

    Wilkinson IB, Prasad K, Hall IR, Thomas A, MacCallum H, Webb DJ, et al. Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia. J Am Coll Cardiol. 2002;39:1005–11.

    Article 

    Google Scholar
     

  • 44.

    Kleefstra N, Houweling ST, Bilo HJ. Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. Diabetes Care. 2007;30:e102.

    Article 

    Google Scholar
     

  • 45.

    Institute of Medicine Panel on M. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington (DC): National Academies Press (US) Copyright 2001 by the National Academy of Sciences. All rights reserved. 2001.

  • 46.

    Heimbach JT, Anderson RA. Chromium: recent studies regarding nutritional roles and safety. Nutr Today. 2005;40:189–95.

    Article 

    Google Scholar
     

  • Products You May Like

    Leave a Reply

    Your email address will not be published. Required fields are marked *