The alliance is aimed at advancing GentiBio’s immune tolerance platform; that company is developing engineered regulatory T cells (Tregs) that are programmed to treat autoimmune, alloimmune, autoinflammatory, and allergic diseases.
Forge, which is a contract and development manufacturing organization (CDMO) focused on accelerating cell and gene therapy (CGT) programs from preclinical through clinical and commercial stage manufacturing, is to provide adeno-associated viral (AAV) vector process and analytical development, scale-up engineering and GMP manufacturing services for GentiBio’s engineered Tregs therapeutic candidates.
The CDMO said its Blaze Vector production platform and HEK 293 Suspension Ignition Cells will be employed to facilitate GentiBio’s development process.
All development and GMP activities will occur Forge’s gene therapy GMP production facility in Columbus, Ohio.
Keeping the immune system in check
GentiBio said its proprietary autologous and allogeneic EngTregs platform is designed to integrate complementary technologies aimed at restoring immune tolerance and to overcome the major limitations in existing Tregs cell-based therapeutics; it is looking to leverage a therapeutic modality that can be used to address the fundamental cause of many diseases that result from overactivity and/or malfunctioning of the immune system.
Tregs are said to play a central role in keeping the immune system in check by applying the brakes to maladaptive immune responses.
The emerging biotherapeutics player said its EngTregs are scalable. “Rather than isolating Tregs – a very rare population in the blood, we zero in on more abundant effector T cells to generate our EngTregs. Our technology stably converts the effector T cells into EngTregs and ensures our ability to scale manufacturing at very efficient costs.”