The collaboration covers R&D of ‘off-the-shelf’ cell therapies for up to five shared cancer targets along with the development of a novel allogeneic personalized cell therapy platform.
The partners have not disclosed any details on indications or likely targets.
The UK biotech will receive US$150m upfront, as well as US$150m over the next five years in additional payments, and development, regulatory and commercial milestones payments potentially exceeding US$3bn in aggregate value, combined with royalties, across multiple programs.
Adaptimmune also has the right to opt in to a 50/50 US profit/cost share on ‘off-the-shelf’ products.
Adrian Rawcliffe, Adaptimmune’s CEO, said the idea behind this collaboration is that eventually any patient can receive a T-cell product for their cancer. It is “a significant step towards our goal of making cell therapies both curative and mainstream.”
James Sabry, global head of pharma partnering at Roche, commented. “This partnership, which combines Adaptimmune’s allogeneic platform with Genentech’s expertise in developing personalized therapies, complements our other efforts to discover and develop personalized cell therapies. It holds the promise to change how we treat cancer and brings us another step closer to making personalized healthcare a reality.”
Engineered TCRs
The collaboration agreement will not include CAR-T approaches, the focus is on T cell receptors (TCRs).
For each component of the collaboration, Adaptimmune will take on the development of clinical candidates using its induced pluripotent stem cell (iPSC) derived allogeneic platform to produce T-cells (iT cells). Genentech will be responsible for the input TCRs and subsequent clinical development and commercialization.