Clinical Trials & Research

The combination of a novel blood test and magnetic resonance imaging (MRI) can reduce overdiagnosis of low-risk cancers as well as societal costs in prostate cancer screening, according to a cost-effectiveness study from Karolinska Institutet published in the journal European Urology. The results provide support for organized prostate cancer testing in Sweden, researchers say. A

Phenolic contents in vegetable tablets with/without probiotics Phenolic compounds are secondary metabolites found in most plants with health beneficial effects including antioxidant and anti-inflammatory properties11. Many studies reported the strongly positive correlation between phenolic compound content and antioxidant activity12. Daily consumption of fruit and vegetable has been widely recommended because phenolic compound are associated with a

Eating more meat, having less of certain bacteria in the gut, and more of certain immune cells in the blood, all link with multiple sclerosis, reports a team of researchers led by UConn Health and Washington University School of Medicine. The work, published in the 27 January issue of EBioMedicine, teased out subtle connections that

1. WHO. Report of the Commission on Ending Childhood Obesity: Geneva, Switzerland, 2016. 2. Abarca-Gómez L, Abdeen ZA, Hamid ZA, Abu-Rmeileh NM, Acosta-Cazares B, Acuin C, et al. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and

Betty Chow, a Los Angeles resident, had a cervical disc replaced in August 2020 at a surgery center that was part of her Anthem Blue Cross PPO network. Thirteen months later, she was blindsided by a bill for nearly $2,000 from the anesthesiologist who was on her surgical team but was not contracted with her

In this study, three dietary patterns were identified among the Yi people who lived in the Liangshan District of Sichuan Province, China. These three dietary patterns were meat-based, plant-based, and specific cuisine. The main finding of this study is that the meat-based food pattern, which is characterized by a high intake of animal organ meats,

In a recent study posted to the medRxiv* pre-print server, a team of researchers assessed how serial intervals of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron and Delta variants varied during the same time period in the Netherlands. Study: Shorter serial intervals in SARS-CoV-2 cases with Omicron variant compared to Delta variant in the

1. Shaw, J. E., Sicree, R. A. & Zimmet, P. Z. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 87, 4–14 (2010). CAS  PubMed  Google Scholar  2. Baynes, H. W. Classification, pathophysiology, diagnosis and management of diabetes mellitus. J. Diabetes Metab. 6, 1–9 (2015). Google Scholar  3. Eppens,

A new study by researchers from the University of Kent and the Goethe University Frankfurt shows that the SARS-CoV-2 Omicron variant is less effective than Delta at blocking a cellular defense mechanism against viruses, the so-called “interferon response”. Moreover, cell culture findings indicate that eight important COVID-19 drugs and drug candidates remain effective against Omicron.

RESEARCH HIGHLIGHT 20 January 2022 Understanding microbiome alterations in autism Microbiome alterations have been associated with autism, but a new study suggests that this may be a consequence of autism-related dietary preferences, rather than a causal factor. Karen O’Leary 0 Karen O’Leary Karen O’Leary is an Associate Research Analysis Editor with Nature Medicine. View author

This article will give an example of a study demonstrating how a GCP standard trial design can deliver successful results for a Sponsor when researching variable and subjective health conditions in mild symptoms of the self-diagnostic populations or in healthy populations. About the Sponsor It was the intention of a well-established multinational company to gain

Rapid, accessible and highly accurate detection of addictive substances such as opiates and cocaine is vital to reducing the adverse personal and societal impacts of addiction, something current drug detection systems can take too long to provide. However, on-site, real-time monitoring of abused drugs in a patient’s system could alert clinicians before dangerous levels are

As Covid-19 resurges, propelled by the emergence of the omicron variant, and by the reduced effectiveness of the Covid vaccines over time [1], many people are asking what can be done to prevent “breakthrough” infections in vaccinated people and what can turn the tide on the pandemic overall. Recent studies show what may be a

This article presents a case study of a human clinical study designed and conducted at Atlantia Clinical Trials’ Cork Facility in Ireland. The Sponsor required a trusted research partner to recruit 80 healthy overweight volunteers and assess the efficacy of their investigational product versus placebo on FMD. About the Sponsor An important role in cardiovascular

In a recent study, Japanese researchers report that the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, Omicron, has higher environmental stability than previous variants. Study: Differences in environmental stability among SARS-CoV-2 variants of concern: Omicron has higher stability. Fit Ztudio/Shutterstock The study, posted on the preprint server bioRxiv*, compared the SARS-CoV-2 Wuhan strain

1. Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet Lond Engl. 2018;390:2769–78. 23 de Google Scholar  2. Ng SC, Bernstein CN, Vatn MH, Lakatos PL, Loftus EV, Tysk C, et

Atlantia Clinical Trials designed and carried out a human clinical trial to assess the outcome of probiotic supplementation in sleep quality and its implications on immunity. The details of such a study are outlined in this article. Recent studies have demonstrated that circadian clock misalignment, sleep deprivation and shift experience may alter the circadian clock

Deep neural networks are becoming increasingly popular in more and more industries, and while recent developments in networks designed to play Go and online video games have excited the attention of the media, the use of these networks in research is also gaining traction. Most recently, a group of researchers from Drexel University have built

1. Huttunen R, Syrjanen J. Obesity and the risk and outcome of infection. Int J Obes (Lond). 2013;37:333–40. CAS  Google Scholar  2. Fezeu L, Julia C, Henegar A, Bitu J, Hu FB, Grobbee DE, et al. Obesity is associated with higher risk of intensive care unit admission and death in influenza A (H1N1) patients: a

Atlantia Clinical Trials first conducted a pilot study to evaluate the carryover effect and establish the washout period necessary for the randomized, double-blind, placebo-controlled crossover study and deliver preliminary data on the subject characteristics and variation in the measured parameters. Irritable bowel syndrome (IBS) typically pertains to chronic abdominal pain, bloating, discomfort and alteration of

Since the first case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus has evolved into more infectious and deadly variants, for example with the spread of Delta and Omicron. Study: Will the COVID-19 pandemic end with the Delta and Omicron variants? Image Credit: G.Tbov/Shutterstock A new analysis, published in the journal Environmental Chemistry

1. Alatab S, Sepanlou SG, Ikuta K, Vahedi H, Bisignano C, Safiri S, et al. The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol. 2020;5:17–30. Google Scholar  2. Ni J, Wu GD, Albenberg L,