Clinical Trials & Research

Culinary medicine programs are emerging at medical schools to meet a critical need to improve nutrition education in an era of unprecedented diet-related health problems including obesity and cardiovascular disease, according to a review of programs by UT Southwestern researchers published in Academic Medicine, the journal of the Association of American Medical Colleges. The programs

The mental health system is increasingly reliant on psychiatric mental health nurse practitioners (PMHNPs) to meet the psychiatric needs of Medicare patients, according to a new study led by researchers at Harvard T.H. Chan School of Public Health. We were surprised by the degree to which PMHNPs are the de facto mental health prescribers in

Due to their immunosuppressive properties, systemic glucocorticoids are estimated to be used by 0.5% to 3% of the population annually. Glucocorticoids are effective, but their use comes with some significant musculoskeletal and cardiovascular side effects. A recent BMJ Open study conducted a cross-sectional analysis to test the hypothesis that the usage of systemic and inhaled glucocorticoids was

A multidisciplinary team of Indiana University researchers have discovered that the motion of chromatin, the material that DNA is made of, can help facilitate effective repair of DNA damage in the human nucleus — a finding that could lead to improved cancer diagnosis and treatment. Their findings were recently published in the Proceedings of the

In a recent study, researchers from Karolinska Institutet in Sweden, and others, have characterised the new omicron variant BA.2.75, comparing its ability to evade antibodies against current and previous variants. The study, published in the journal The Lancet Infectious Diseases, suggests that BA.2.75 is not more resistant to antibodies than the currently dominating BA.5, which

This prespecified subgroup analysis of East Asian adults who participated in a phase 3 clinical trial of belimumab added to standard therapy vs. placebo added to standard therapy for lupus nephritis shows earlier and more sustained improvement in kidney outcomes with the addition of belimumab. Related Stories Lupus nephritis (LN) is a severe complication of

Anxiety, autism, schizophrenia and Tourette syndrome each have their own distinguishing characteristics, but one factor bridging these and most other mental disorders is circadian rhythm disruption, according to a team of neuroscience, pharmaceutical sciences and computer science researchers at the University of California, Irvine. In an article published recently in the Nature journal Translational Psychiatry,

Isolating nuclei is a crucial step for single nuclear RNA-sequencing and ATAC-sequencing workflows. Making sure that non-clustered, debris-free samples are produced is vital to effective library preparation. Nuclei isolated from tissue samples often contain greater amounts of debris compared to that from cultured cells. Even when debris does not impact library preparation itself, it is of

Scientists from Germany have developed a novel mathematical model to study the airborne transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Scientists claim that the new model is effective in qualitatively evaluating the risk of exposure. The study is published in the journal PLOS ONE. Study: Modelling airborne transmission of SARS-CoV-2 at a local

Scientists at the Francis Crick Institute, UCL and the University of Edinburgh have uncovered how a build-up of harmful protein starts to happen within neurons in Parkinson’s disease, ultimately causing nerve cell death. By looking at how, where and why this build-up happens, the work provides unique insight into a key biological process driving Parkinson’s.

In a first-of-its-kind randomized clinical trial led by researchers at the Smidt Heart Institute and the Division of Artificial Intelligence in Medicine at Cedars-Sinai, artificial intelligence (AI) proved more successful in assessing and diagnosing cardiac function when compared to echocardiogram assessments made by sonographers. The results, announced today during a late-breaking presentation at the European

Dapagliflozin reduces the risks of death and cardiovascular events in patients with heart failure regardless of ejection fraction, according to late-breaking research presented in a Hot Line session today at ESC Congress 2022. This pre-specified patient-level meta-analysis combined the DAPA-HF and DELIVER trials of the SGLT2 inhibitor dapagliflozin in patients with heart failure. DAPA-HF enrolled

As the saying goes, time is money, and this statement could not be more true for the medical device industry. Each day that passes when a device is not approved for marketing is a day of revenue loss. Sadly, it is also a day when patients will not be able to benefit from the device. Individual country

A study published in the journal Science Translational Medicine has described the transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), population-level immunity, and the impact of the omicron wave in South Africa. Study: SARS-CoV-2 transmission, persistence of immunity, and estimates of Omicron’s impact in South African population cohorts. Image Credit: PHOTOCREO Michal Bednarek/Shutterstock Background

The oldest consumer protection organization in the US is the Food and Drug Administration (FDA). In 1906, the FDA was established to oversee food and drugs. However, up until 1976, there was no monitoring in place for medical devices. The Food, Drug and Cosmetics (FD&C) Act’s Medical Device Amendments put many of the same types of

When the Biden administration announced COVID-19 vaccine mandates on Nov. 4 for businesses with 100 or more employees, protests erupted in cities across the U.S. A recent study of the slogans displayed by protestors found three distinct themes. Tim F. Liao, a professor of sociology at the University of Illinois Urbana-Champaign, analyzed the content of

Study design The HOMEFOOD study was a 6-month, randomized controlled, assessor blinded intervention trial conducted in older adults (age 66–95 years) recruited in the Reykjavik capital area, Iceland between January 2019, and July 2020. The primary aim was to investigate the effects of intense nutritional therapy, including free access to energy- and protein-dense foods delivered

Chemistry, manufacturing, and control (CMC) information strengthens the link between the quality of a drug candidate used in clinical trials and the end product advertised to consumers. It essentially outlines the critical quality attributes for drug products throughout their entire life cycle, from clinical development to commercial-scale production. Image Credit: DSI, a PLG Company CMC reviews,

In a recent study published on the medRxiv* preprint server, researchers map the proteomes of peripheral blood neutrophils isolated from hospitalized coronavirus disease 2019 (COVID-19) patients using high-resolution liquid-chromatography-mass spectrometry (LC-MS). These findings were used to provide evidence of the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on neutrophil phenotypes and their

In vitro starch digestibility in the presence of RP The in vitro digestion results for rice starch before and after the addition of RP are shown in Table 1. The rapidly digestible starch (RDS), slowly digestible starch (SDS), and resistant starch (RS) contents of rice starch were 68.02, 14.44, and 17.54 g/100 g, respectively. The digestion behavior

Babies born with very low birth weight (VLBW), which is defined as less than 1.5 kg at birth, have altered gut microbiota as compared to healthy term babies. This is a risk factor for neonatal growth and slowing/arrest of growth in the hospital. To correct this, nutrition in hospitals could be designed with appropriate microbial

The coronavirus disease 2019 (COVID-19) pandemic, which was caused by the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to persist. The unrelenting nature of the COVID-19 pandemic is largely due to the rapid spread of many mutant SARS-CoV-2 variants that escape immunity elicited by prior infection and/or vaccination. Among the several