Clinical Trials & Research

The European Laboratory Research & Innovation Group (ELRIG) UK today announced the programme details for Drug Discovery 2021, which will take place at the Exhibition Centre ACC in Liverpool, UK, from 19–20 October. The Society for Laboratory Automation and Screening (SLAS), a US-based organisation dedicated to advancing life sciences discovery, technology and collaboration, will host

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, which has claimed more than 4.3 million lives worldwide. Even after implementing various measures, such as vaccination and social restrictions, SARS-CoV-2 and its variants of concern (VoC) leave the world’s public health systems and economies in turmoil. In

The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA. The breakdown of this interaction is a hallmark of many cancers. Now, U-M scientists have determined the structure of a complex of two

Study design This study used data collected from the Generation R Study, a prospective birth-cohort study in the city of Rotterdam, in The Netherlands [18]. We included objectively determined measures of BMI at the age of 4, 6, 10 and 14 years, and DXA-derived measures of fat mass at the age of 6 and 10

A team of University of California, Irvine, scientists have discovered a novel pharmacological approach to attenuate the mitochondrial dysfunction that drives diet-induced obesity. The results of their study were published recently in the journal, EMBO Molecular Medicine. Consuming a high-fat diet can lead to obesity and metabolic disorders such as diabetes and fatty liver. Palmitate,

1. Kaneyasu, M., Nagata, M., Ikeda, H., Ohnuki, K. & Shimizu, K. Anti-allergic activity of lotus root (Nelumbo nucifera) powder in TDI-sensitized nasal allergy model mice. Food Agric. Immunol. 30, 968–978 (2019). CAS  Article  Google Scholar  2. Xu, L., Shi, P. T., Ye, Z. H., Yan, S. M. & Yu, X. P. Rapid analysis of

TARRYTOWN, N.Y., Aug. 4, 2021 /PRNewswire/ – Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that the New England Journal of Medicine (NEJM) published positive detailed results from a Phase 3 trial that assessed the ability of REGEN-COV™ (casirivimab and imdevimab) to prevent COVID-19 infection among household contacts of SARS-CoV-2 infected individuals. The trial met its primary endpoint, reducing the risk of symptomatic infections by 81%

Heart muscle becomes damaged and cardiac function is affected when blood vessels feeding the heart are blocked. A new stem-cell-carrying hydrogel helps mice recover from this condition, called myocardial infarction, by stimulating formation of new blood vessels. Developed by a team of scientists at Kansai University in Japan, the stem cell delivery system is described

Research was conducted to determine the optimum laser diffraction-based particle sizing dispersion method for Domperidone API. This study employed the Bettersizer 2600 – an automatic laser diffraction particle size analyzer featuring a dry and wet dispersion system – which enabled researchers to systematically investigate the particle size distribution of Domperidone API. The study presented here

CHICAGO & CAMBRIDGE, Mass.–(BUSINESS WIRE) August 5, 2021 — Exicure, Inc. (NASDAQ: XCUR), a pioneer in gene regulatory and immunotherapeutic drugs utilizing spherical nucleic acid (SNA™) technology, is providing an update on the Phase 1b/2 clinical trial of cavrotolimod (AST-008) (NCT03684785). The Phase 2 stage of the trial is evaluating cavrotolimod in combination with pembrolizumab

When public health insurance like Medicaid expands its dental coverage, by increasing the types of procedures it covers and the total amount a dentist can spend on an individual patient, more dentists will locate to the expansion areas, therefore increasing access. This finding comes from research recently published in the Journal of Public Economics by

INDIANAPOLIS, July 29, 2021 /PRNewswire/ – Eli Lilly and Company (NYSE: LLY) and Incyte (NASDAQ:INCY) announced today the U.S. Food and Drug Administration (FDA) has broadened the Emergency Use Authorization (EUA) for baricitinib to allow for treatment with or without remdesivir, whereas the EUA was previously restricted to use only in combination with remdesivir. The EUA now provides for

Pooled results from recent clinical trials indicate that an oral drug called roxadustat is an effective treatment for anemia in patients with chronic kidney disease. The results are published in an upcoming issue of CJASN. Many individuals with kidney dysfunction develop anemia, or a shortage of healthy red blood cells that carry oxygen to the

1. Sistema Nazionale Linee Guida. Linea guida 2011 – Gravidanza fisiologica. Linee Guida ISS. 2011. https://www.salute.gov.it/imgs/C_17_pubblicazioni_1436_allegato.pdf. 2. Ghiotti P. Nascere in Piemonte: percorso nascita regionale. 2006–2016. https://www.epi.piemonte.it/pubblicazioni/atlanti/nascere_in_piemonte_2006_2016.pdf. 3. Benedetto C, Marozio L, Lanzo G. Patologia della gravidanza – Ipertensione in gravidanza. In: Benedetto C, Sismondi P, editors. Ginecologia e Ostetricia. Torino: Minerva Me. 2013. p.

STAMFORD, Conn., Aug. 03, 2021 (GLOBE NEWSWIRE) — SpringWorks Therapeutics, Inc. (Nasdaq: SWTX), a clinical-stage biopharmaceutical company focused on developing life-changing medicines for patients with severe rare diseases and cancer, today announced that the Company will be evaluating mirdametinib, an investigational MEK inhibitor, in a platform study sponsored by Memorial Sloan Kettering Cancer Center (MSK)

A single cell can reveal much about the biological world through genomic sequencing. Scientists can compare a single, isolated cell to other samples, analyzing the differences and similarities to better understand how the organisms originated and evolved -; or even to discover entirely new species. However, despite the rapid development of single-cell sequencing technologies, sample

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International Gas Detectors has developed the SENKO iGAS Personal CO2 Monitor to detect the presence of carbon dioxide (CO2) gas in limited spaces, and it enables users to instantly detect the gas. Image Credit: International Gas Detectors Ltd A low-power non-dispersive infrared (NDIR) sensor is utilized by the SENKO iGAS Personal CO2 Monitor to allow

NEW YORK–(BUSINESS WIRE) August 04, 2021– Pfizer Inc. (NYSE: PFE) today announced positive top-line results from the Phase 2b/3 ALLEGRO trial evaluating oral once-daily ritlecitinib in patients with alopecia areata, an autoimmune disease driven by an immune attack on the hair follicles that causes hair loss on the scalp and can also affect the face

Stroke patients were almost twice as likely to be functionally independent-;mobile and able to perform daily tasks-;at 90 days post-stroke if they were treated by a specialized mobile stroke team that traveled to them to perform mechanical clot removal, compared to those who were transferred to a thrombectomy stroke center, according to research conducted within

For applications like oxygen depletion and enrichment, the SGT-P portable oxygen detector from International Gas Detectors is the ideal solution. It is a compact and lightweight device that has an ergonomic design, making it the perfect personal detection device. Image Credit: International Gas Detectors Ltd In order to make it eco-friendly and to decrease monitor